Ganfort PF Overdosage

Overdose and Treatment: No information is available on overdosage with Ganfort PF in humans. If overdosage occurs, treatment should be symptomatic and supportive; a patient airway should be maintained.
If Ganfort PF is accidentally ingested, the following information may be useful: in 2-week oral rat and mouse studies, doses of bimatoprost up to 100 mg/kg/day did not produce any toxicity.
This dose is at least 22 times higher than the amount of bimatoprost to which a 10 kg child would be exposed were it to accidentally ingest the entire content of a package (30 unit dose vials; 0.4 mL per vial; 12 mL) of bimatoprost 0.03% ophthalmic solution.
There have been reports of inadvertent overdosage with timolol ophthalmic solution resulting in systemic effects similar to those seen with systemic beta-adrenergic blocking agents such as dizziness, headache, shortness of breath, bradycardia, hypotension, bronchospasm, and cardiac arrest. An in vitro hemodialysis study, using ¹⁴C timolol added to human plasma or whole blood showed that timolol was readily dialyzed from these fluids; however, a study of patients with renal failure showed that timolol did not dialyze readily.